ABOUT MIRACLE

Mission statement

Our mission is to build and foster an innovative doctoral program designed to equip a team of young scientists with the critical scientific and technical expertise in single-cell and artificial intelligence technologies. This will enable them to uncover the intricate layers of inflammatory regulation in cardiometabolic disease. 

Cardiometabolic disease

Cardiometabolic diseases are the leading cause of death worldwide. They include a range of heart and metabolic conditions like heart disease, type 2 diabetes, and a liver condition called non-alcoholic steatohepatitis, all linked by common risk factors. Catching and treating these diseases early is key to reducing their impact on health systems. For example, early stages of insulin resistance can lead to diabetes and metabolic syndrome if not managed well and may eventually result in more serious problems like heart attacks, heart failure, strokes, or Alzheimer’s disease.

Low-grade inflammation

Chronic, ongoing inflammation is a key factor in the development and progression of cardiometabolic diseases. This type of inflammation is influenced by immune cells that operate in specific areas and times, working both locally and throughout the body to impact the disease and its effects on health and disease.

Our main goal

Emerging technologies

Our main goal is to explore the complex nature of cardiometabolic diseases using advanced technology. We're focusing on:

  • Using Single Cell Technologies: We're diving into the microscopic world of immune cells with single cell technologies. This allows us to find new types of immune cells and understand their roles in disease, using computers to make sense of the massive amounts of data we collect.
  • Studying Cells in Their Environment: We're looking at how cells interact with their surroundings, including inflammation and other cells, to understand how these interactions affect diseases. We're using advanced imaging and sequencing techniques to get a full picture of these interactions.
  • Combining Multiple Types of Data (Multi-Omics): We're examining how genetics and environment influence cell behavior and disease development. This involves integrating genetic information with detailed cell data to pinpoint factors that contribute to disease.
  • Creating New Disease Models: We're developing models to test potential new treatments for diseases. This includes organ-on-chip technology and digital simulations to understand and combat the inflammation processes in diseases better.